Napoli vs Pisa Prediction: Home Champions to Cover -1.5 Handicap

September 22, 2025 4:39 AM
Soccer Genius
Betting Tips
3 min read
In the 4th round of Italy's Serie A on September 22, 2025, Napoli will face Pisa. The reigning champion is clearly expected to play only for victory against the newcomer.
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In the 4th round of Italy's Serie A on September 22, 2025, Napoli will face Pisa. The reigning champion is clearly expected to play only for victory against the newcomer.

Our Prediction for Napoli vs Pisa

The team from Naples experienced a sharp decline after their previous championship triumph. However, with the arrival of Conte as head coach last summer, expectations were exceeded—he even overtook Inter in the final stretch to reclaim the "Scudetto." This happened despite Kvaratskhelia's departure in the winter! In the summer, Lukaku suffered an injury, but he was partially replaced by his national teammate, De Bruyne. De Bruyne scored in his debut match, helping defeat Sassuolo. The team then also beat Cagliari. This month, they started with a match against Fiorentina, winning 3-1. In midweek, against Manchester City, they played with ten men from the middle of the first half and couldn’t hold out, eventually losing 0-2.

The visitors had not played in the country’s top division for 34 years, and their last promotion to Serie B was in 2019. Last season, under Inzaghi's leadership, they finished second in Serie B. Now without Filippo and with Gilardino as coach, they passed Cesena in the cup on penalties after a goalless draw, then drew 1-1 with Atalanta in Serie A and narrowly lost to Roma due to a single goal from Soulé. They repeated this negative result against Udinese.

Antonio’s side has averaged 2.0 goals scored and 0.33 conceded per game. The newcomer averages 1.0 goals scored and 0.33 conceded per match.

Napoli vs Pisa: Key Statistics and Trends

  • Napoli has won three Serie A matches in a row

  • 33% of Napoli's matches end with goals from both teams, with an average total of 2.33 goals per match

  • Pisa has not won in four matches

  • 33% of Pisa's matches end with goals from both teams, with an average total of 1.33 goals per match

Napoli vs Pisa: Probable Starting Lineups

Napoli (probable lineup): Meret – Spinazzola, Jesus, Rrahmani, Di Lorenzo – McTominay, Lobotka, De Bruyne, Zambo Anguissa, Politano – Lucca

Pisa (probable lineup): Šemper – Lusuardi, Caracciolo, Canestrelli – Angori, Tramoni, Aebischer, Marin, Touré – Meister, Moreo

Previous Meetings: Napoli vs Pisa

In five matches played, Napoli won three times, with two draws.

Free Prediction for Napoli vs Pisa

The champion at home against the newcomer—it seems everything points to a win for the hosts; the only question is how big the margin will be. We predict a handicap of "-1.5 goals" (odds – 1.86).

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Napoli vs Pisa Prediction
Published: September 21, 2025 at 12:37 PM
Updated: September 22, 2025 at 4:39 AM

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